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KMID : 1059520110550060952
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Journal of the Korean Chemical Society
2011 Volume.55 No. 6 p.952 ~ p.959
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Synthesis and Cytotoxicity Evaluation of Phosphorylated Derivatives of Ribavirin
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Valasani Koteswara Rao
Sanapalli Subba Reddy
Kilaru Raveendra Babu
Chamarthi Naga Raju
Kuntrapakam Hema Kumar
Sunil Kumar Ghosh
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Abstract
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Novel phosphorylated derivatives of ribavirin 5-16 were synthesized by the reaction of 4-nitrophenyl phosphorodichloridate with various amino acid esters in the presence of triethylamine in dry tetrahydrofuran through the intermediates 3. On further reaction of 3 with ribavirin in THF and pyridine in the presence of TEA afforded the title compounds 5-16. Their structures were characterized by IR, 1H, 13C, 31P NMR and mass spectral analyses. All the title compounds were found to exhibit potent in vitro anticancer activity against MCF-7 breast cancer cell lines.
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KEYWORD
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Phosphorylated ribavirins, Trypan blue assay, MTT assay, MCF-7 cell lines
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